No prior data exist on MLCs in eyes with severe NPDR or DME. Vision-threatening diabetic retinopathy (VTDR) includes PDR, severe non-PDR (NPDR), and diabetic macular edema (DME). We previously showed that MLCs are increased in proliferative diabetic retinopathy (PDR) eyes. Macrophage-like cells (MLCs) are potential inflammatory biomarkers.
#HEIDELBERG OPTICAL COHERENCE TOMOGRAPHY REGISTRATION#
Trial registration The protocol was published in the Chinese Clinical Trial Registry (ChiCTR2000033082). Greater severity level of DME, larger FAZ area, and increased foveal thickness could be risk factors for poor visual acuity. In the multivariate generalized estimating equation, DME severity, FAZ area and foveal thickness were positively associated with worse visual acuity ( P = 0.001, P = 0.007 and P = 0.001, respectively).Ĭompared to early and advanced DME, severe DME showed increased irregularity in the FAZ and more extensive vessel damage in the DVP. Both whole and parafoveal VD in the DVP decreased in eyes with severe DME compared to early DME ( P = 0.018, P = 0.005, respectively) and advanced DME ( P = 0.035, P = 0.012, respectively). Compared to early ( P = 0.006) and advanced DME ( P = 0.003), the acircularity index was higher in severe DME. Ninety-two eyes from 74 patients with DME were included in this study. A multivariate generalized estimating equation was used to evaluate the associations between visual acuity and OCTA metrics. The vessel density (VD) in the superficial vascular plexus (SVP), deep vascular plexus (DVP) and foveal avascular zone (FAZ) parameters, including FAZ area, FAZ perimeter, acircularity index and foveal VD in a 300-μm-wide region around the FAZ (FD-300), were calculated by the AngioVue software. DME was classified into early, advanced, and severe DME. Patients diagnosed with DME were recruited. To investigate the optical coherence tomography angiography (OCTA) characteristics of diabetic macular edema (DME) at different stages.
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